Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.

Aurélie A G Gabriel Joshua R Atkins Ricardo Cortez Cardoso Penha Karl Smith ByrneValerie GaborieauCatherine VoegeleBehnoush Abedi-Ardekani Maja Milojevic Robert Olaso Vincent Meyer Anne Boland-Auge Jean François Deleuze David ZaridzeAnush MukeriyaBeata Świątkowska Vladimír JanoutMiriam SchejbalováDana Mates Jelena StojšićMiodrag Ognjanovicnull nullJohn S WitteSara R Rashkin Linda Kachuri Rayjean J Hung Siddhartha P Kar Paul J Brennan Anne-Sophie SertierAnthony FerrariAlain Viari Mattias J Johansson Christopher Ian Amos Matthieu Foll James D McKay

Published in: Journal of the National Cancer Institute (2022)

This study has expanded the number of LC susceptibility loci and provided insights into the molecular mechanisms by which these susceptibility variants contribute to LC development.

Keyphrases

copy number
simultaneous determination
mass spectrometry
dna repair
liquid chromatography
gene expression
risk factors
oxidative stress
dna methylation
solid phase extraction
tandem mass spectrometry
high resolution
genome wide association