Chemokine CCL7 mediates trigeminal neuropathic pain via CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice.

Lin-Peng ZhuMeng-Lin XuBao-Tong YuanLing-Jie Ma Yong-Jing Gao

Published in: Molecular pain (2023)

CCL7 activates ERK in TG neurons via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. CCL7-CCR2/CCR3-ERK pathway may be potential targets for treating trigeminal neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
dendritic cells
regulatory t cells
signaling pathway
cell proliferation
pi k akt
liver fibrosis
liver injury
type diabetes
skeletal muscle
climate change
working memory
transcranial direct current stimulation
optic nerve