Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case.
Sanjay S GautamMicheál Mac AogáinLouise A CooleyGreg HaugJanet A FyfeMaria GlobanRonan F O'ToolePublished in: PloS one (2018)
TB in Tasmania is predominantly of overseas origin with genotypically-unique drug-susceptible isolates of M. tuberculosis. However, the state also exhibits features of TB that are observed in other jurisdictions, namely, the clustering of cases, and drug resistance. Early detection of TB and contact tracing, particularly of overseas-born cases, coordinated with rapid laboratory drug-susceptibility testing and molecular typing, will be essential for Tasmania to reach the World Health Organisation's TB eradication goals for low-incidence settings.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- multidrug resistant
- pulmonary tuberculosis
- acinetobacter baumannii
- adverse drug
- public health
- risk factors
- genetic diversity
- hiv aids
- emergency department
- copy number
- pseudomonas aeruginosa
- dna methylation
- african american
- hiv infected
- health promotion
- loop mediated isothermal amplification
- gestational age
- cystic fibrosis
- antiretroviral therapy