Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark.
Juliana de Almeida-FariaDaniella E Duque-GuimarãesThomas P OngLucas C PantaleãoAsha A CarpenterElena LocheLaura C KusinskiThomas J AshmoreRobin AntrobusMartin BushellDenise S Fernandez-TwinnSusan E OzannePublished in: Diabetologia (2021)
Concurrently targeting IRS-1 and Lunapark, a nutritionally programmed increase in miR-126-3p causes adipose tissue insulin resistance and an ER stress response, both of which may contribute to impaired glucose tolerance. These findings provide a novel mechanism by which obesity during pregnancy leads to increased risk of type 2 diabetes in the offspring and therefore identify miR-126-3p as a potential therapeutic target.
Keyphrases
- insulin resistance
- adipose tissue
- high fat diet induced
- high fat diet
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- cell proliferation
- type diabetes
- long non coding rna
- pregnant women
- weight loss
- cancer therapy
- long noncoding rna
- birth weight
- climate change
- breast cancer cells
- weight gain
- endoplasmic reticulum
- physical activity