Temporal pathway analysis of cerebrospinal fluid proteome in herpes simplex encephalitis.

Anja NääsPeng LiClas AhlmElisabeth AureliusJosef D JärhultSilvia SchliamserMarie StudahlWenzhong XiaoJonas Bergquist Gabriel Westman

Published in: Infectious diseases (London, England) (2023)

We show a temporal change in the CSF proteome in HSE patients during the course of the disease. This study provides insight into quantitative and qualitative aspects of the dynamic pathophysiology and pathway activation patterns in HSE and prompts for future studies on the role of apolipoprotein A1 in HSE, which has previously been associated with NMDAR encephalitis.

Keyphrases

cerebrospinal fluid
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
systematic review
high resolution
patient reported outcomes
mass spectrometry
patient reported