Choosing the right strategy based on individualized treatment effect predictions: combination versus sequential chemotherapy in patients with metastatic colorectal cancer.

Johannes J M KwakmanRob C M van KruijsdijkSjoerd G EliasMatthew T SeymourAngela M MeadeFrank L J VisserenCornelis J A Punt Miriam Koopman

Published in: Acta oncologica (Stockholm, Sweden) (2019)

We successfully developed individualized prediction models including prognostic characteristics derived from randomized trials to estimate treatment effects in mCRC patients. In times where the heterogeneity of CRC becomes increasingly evident, such tools are an important step towards personalized treatment.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
radiation therapy
peritoneal dialysis
prognostic factors
single cell
replacement therapy