Inhibiting autophagy potentiates the antitumor efficacy of Euphorbia royleana for canine mammary gland tumors.
Yu-Ya HuangChia-Hung ChenChia-Hui HsuTsun-Yung KuoCheng-Chi LiuAlbert Tai-Ching LiaoChen-Si LinPublished in: BMC veterinary research (2020)
The anti-tumor mechanisms of E. royleana were firstly verified to show it would cause autophagic cell death, apoptosis, and cell cycle arrest in canine mammary tumor cells. The in vitro and in vivo findings in the present study revealed E. royleana has potential anticancer effects for the treatment of canine mammary gland tumors.