Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo.

Published in: Stem cell research & therapy (2021)

BMSCs and their derived exosomes offer neuroprotection against DOX-induced chemobrain via genetic and epigenetic abrogation of hippocampal neurodegeneration through modulating Wnt/β-catenin and hedgehog signaling pathways and through reducing inflammatory, apoptotic, and oxidative stress state. Proposed mechanisms of the protective effects of bone marrow stem cells (BMSCs) and their exosomes (BMSCs-Exo) in doxorubicin (DOX)-induced chemobrain. Blue arrows: induce. Red arrows: inhibit.

Keyphrases

stem cells
diabetic rats
oxidative stress
mesenchymal stem cells
high glucose
bone marrow
cell proliferation
drug induced
dna methylation
epithelial mesenchymal transition
dna damage
endothelial cells
cell therapy
brain injury
cancer therapy