Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability.
Rick H van GorpConstance C F M J BaatenAnxhela HabibiArmand M G JaminonFrederique E C M PeetersPeter LeendersHarry J G M C CrijnsJohan W M HeemskerkChris P ReutelingspergerHenri M SpronkLeon J SchurgersPublished in: European heart journal open (2021)
Oral anticoagulation with VKA aggravates vascular calcification and atherosclerosis. VSMC phenotype differentiation impacts coagulation potential in a TF-dependent manner. VKA-induced vascular calcification increases hypercoagulability and could thereby potentially positively affect atherothrombosis.