Tumor-derived exosomal BCYRN1 activates WNT5A/VEGF-C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer.

Hanhao ZhengChanghao ChenYuming LuoMin YuWang HeMingjie AnBowen GaoYao KongYiyao YaYan LinYuting LiKeji XieJian HuangTianxin Lin

Published in: Clinical and translational medicine (2022)

Our results uncover a novel mechanism by which exosomal BCYRN1 synergistically enhances VEGF-C/VEGFR3 signaling-induced lymphatic metastasis of BCa, indicating that BCYRN1 may serve as an encouraging therapeutic target for patients with BCa.

Keyphrases

vascular endothelial growth factor
endothelial cells
lymph node
high glucose
stem cells
cell proliferation
diabetic rats
transcription factor
drug induced
oxidative stress