Tumor-derived exosomal BCYRN1 activates WNT5A/VEGF-C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer.
Hanhao ZhengChanghao ChenYuming LuoMin YuWang HeMingjie AnBowen GaoYao KongYiyao YaYan LinYuting LiKeji XieJian HuangTianxin LinPublished in: Clinical and translational medicine (2022)
Our results uncover a novel mechanism by which exosomal BCYRN1 synergistically enhances VEGF-C/VEGFR3 signaling-induced lymphatic metastasis of BCa, indicating that BCYRN1 may serve as an encouraging therapeutic target for patients with BCa.