Suppressed IgG4 class switching in dupilumab- and TNF inhibitor-treated patients after mRNA vaccination.
Anika M ValkJim B D KeijserKoos P J van DamEileen W StalmanLuuk WieskeMaurice SteenhuisLaura Y L KummerPhyllis I SpulsMarcel W BekkenkAnnelie H MustersNicoline F PostAngela L BosmaBarbara HorváthDirk-Jan HijnenCorine R G SchreursZoé L E van KempenJoep KillesteinAdriaan G VolkersSander W TasLaura BoekelGerrit J WolbinkSofie KeijzerNinotska I L DerksenMelanie van DeelenGerard van MierloTaco W KuijpersFilip EftimovS Marieke van HamAnja Ten BrinkeTheo Rispensnull nullPublished in: Allergy (2024)
Our results imply a critical role for IL-4/IL-13 as well as TNF in vivo IgG4 class switching. These novel findings advance our understanding of IgG4 class switch dynamics, and may benefit humoral tolerance induction strategies, treatment of IgG4 pathologies and mRNA vaccine optimization.