Glycosylated Hemoglobin in Subjects Affected by Iron-Deficiency Anemia.
Jari IntraGiuseppe LimontaFabrizio CappelliniMaria BertonaPaolo BrambillaPublished in: Diabetes & metabolism journal (2018)
Previous studies have suggested that iron-deficiency anemia affects glycosylated hemoglobin (HbA1c) measurements, but the results were contradictory. We conducted a retrospective case-control study to determine the effects of iron deficiency on HbA1c levels. Starting with the large computerized database of the Italian Hospital of Desio, including data from 2000 to 2016, all non-pregnant individuals older than 12 years of age with at least one measurement of HbA1c, cell blood count, ferritin, and fasting blood glucose on the same date of blood collection were enrolled. A total of 2,831 patients met the study criteria. Eighty-six individuals were diagnosed with iron-deficiency anemia, while 2,745 had a normal iron state. The adjusted means of HbA1c were significantly higher in anemic subjects (5.59% [37.37 mmol/mol]), than those measured in individuals without anemia (5.34% [34.81 mmol/mol]) (P<0.0001). These results suggest that clinicians should be cautious about diagnosing prediabetes and diabetes in individuals with anemia.
Keyphrases
- iron deficiency
- blood glucose
- glycemic control
- type diabetes
- end stage renal disease
- newly diagnosed
- healthcare
- cardiovascular disease
- pregnant women
- single cell
- emergency department
- palliative care
- blood pressure
- prognostic factors
- tyrosine kinase
- cell therapy
- red blood cell
- physical activity
- adverse drug
- electronic health record
- metabolic syndrome
- machine learning
- patient reported outcomes
- skeletal muscle