Intranasal administration of abatacept enhances IL-35+ and IL-10+ producing Bregs in lung tissues of ovalbumin-sensitized asthmatic mice model.

Maha Fahad AlenazyFatemeh Saheb Sharif-AskariMohammed S El-WetidyNarjes Saheb Sharif-AskariIbrahim Yaseen HachimMohammad-Hani TemsahBasema SaddikRoua Al-KufaidyMaha A OmairYasser A AlshawakirAmany Adulgadel FathaddinSuad HannawiQutayba HamidMohammed A OmairSaleh Al-MuhsenRabih Halwani

Published in: PloS one (2022)

These results suggest that abatacept by enhancing IL-35+IL-10+ Bregs and LAG3+ Tregs might reverse IL-17 induced lung inflammation during asthma.

Keyphrases

rheumatoid arthritis
lung function
metabolic syndrome
adipose tissue
skeletal muscle
systemic lupus erythematosus
drug induced
insulin resistance
disease activity