CaMKII Mediates TGFβ1-Induced Fibroblasts Activation and Its Cross Talk with Colon Cancer Cells.

Wei ChenYanwei ChenJuan SuJian KangYijuan DingWen AiJun ZhangHesheng LuoPing An

Published in: Digestive diseases and sciences (2021)

These findings provide evidence that CaMKII is a critical mediator in TGFβ1-induced fibroblasts activation and is involved in the cross talk with colon cancer cells. CaMKII is a potentially effective target for future treatment of colon cancer.

Keyphrases

high glucose
diabetic rats
transforming growth factor
drug induced
oxidative stress
endothelial cells
combination therapy