The power of representation: Statistical analysis of diversity in US Alzheimer's disease genetics data.

Diane XueElizabeth E BlueMatthew P ConomosAlison E Fohner

Published in: Alzheimer's & dementia (New York, N. Y.) (2024)

AD genetics datasets are largely representative of US ADRD burden. However, there is a wide discrepancy between proportional representation and statistically meaningful representation. Most variation identified in GWAS of non-Hispanic White individuals have low to moderate effects. Comparable risk variants in non-White populations are not detectable given current sample sizes, which could lead to disparities in future studies and drug development. We urge AD genetics researchers and institutions to continue investing in recruiting diverse participants and use community-based participatory research practices.

Keyphrases

healthcare
primary care
neural network
electronic health record
copy number
cognitive decline
big data
risk factors
machine learning
african american
case control
dna methylation
health insurance