Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease.

Marta CarmoFrancisco Q GonçalvesPaula M CanasJean-Pierre OsesFrancisco D FernandesFilipe V DuarteCarlos M PalmeiraAngelo R ToméPaula AgostinhoGeanne M AndradeRodrigo A Cunha

Published in: British journal of pharmacology (2019)

Our data indicate that increased ATP-derived adenosine formation is responsible for A2A receptor over-activation in PD, suggesting CD73 as a new target to manage PD.

Keyphrases

protein kinase
nk cells
electronic health record
machine learning
deep learning