Population pharmacokinetics of ethambutol in African children: a pooled analysis.
Tjokosela TikisoHelen McIlleronMahmoud Tareq AbdelwahabAdrie BekkerAnneke HesselingChishala ChabalaGeraint DaviesHeather J ZarHelena RabieIsabelle Andrieux-MeyerJanice LeeLubbe WiesnerMark F CottonPaolo DentiPublished in: The Journal of antimicrobial chemotherapy (2022)
To obtain exposure within the 2-6 mg/L recommended range for Cmax, the current doses must be doubled (or tripled with HIV+ children on lopinavir/ritonavir) for paediatric patients. This raises concerns regarding the potential for ocular toxicity, which would require evaluation.
Keyphrases
- end stage renal disease
- antiretroviral therapy
- young adults
- ejection fraction
- chronic kidney disease
- newly diagnosed
- hiv infected
- human immunodeficiency virus
- hiv positive
- intensive care unit
- hepatitis c virus
- emergency department
- peritoneal dialysis
- prognostic factors
- oxidative stress
- hiv aids
- hiv testing
- climate change
- optical coherence tomography