Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size.

Mars StoneDaniel I S RosenbloomPeter BacchettiXutao DengMelanie DimapasocSheila KeatingSonia BakkourDouglas D RichmanJohn W MellorsSteven G DeeksJun LaiSubul BegJanet D SilicianoAmélie PagliuzzaNicolas ChomontCarol Lackman-SmithRoger G PtakMichael P Busch

Published in: The Journal of infectious diseases (2022)

The data offer cautious support for use of next-generation QVOAs as proxies for more laborious QVOA, while providing greater sensitivities and dynamic ranges. Measurement of latent reservoirs in eradication strategies would benefit from high throughput and scalable assays.

Keyphrases

human immunodeficiency virus
high throughput
hepatitis c virus
antiretroviral therapy
single cell
hiv infected
sars cov
electronic health record
hiv aids
helicobacter pylori infection
hiv positive
water quality
hiv testing