Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis.

Carlos Alberto-Silva Fernanda Calheta Vieira PortaroRoberto Tadashi KodamaHalyne Queiroz PantaleãoMarisa RangelKen-Ichi NiheiKatsuhiro Konno

Published in: The journal of venomous animals and toxins including tropical diseases (2021)

Comprehensive LC-MS and MS/MS analyses from the Scolia decorata ventralis venom displayed the component profile of this venom. β-scoliidine showed an effective cytoprotective effect, probably due to the observed increase in the number of cells. This is the first report of solitary wasp venom peptides showing neuroprotective activity.

Keyphrases

ms ms
induced apoptosis
cerebral ischemia
amino acid
rare case
blood brain barrier
cell proliferation