Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.
Jennifer M WaltersEung Chang KimJiaren ZhangHan Gil JeongArchit BajajBrian C BaculisGregory C TracyBaher IbrahimCatherine A Christian-HinmanDaniel A LlanoGraham R HuesmannHee Jung ChungPublished in: Epilepsia (2022)
. We propose that the antiseizure effects of TC-2153 are mediated by its unexpected action on suppressing neuronal intrinsic excitability.