Intratumoral genetic and immune microenvironmental heterogeneity in T4N0M0 (diameter ≥ 7 cm) non-small cell lung cancers.
Wen-Zhao ZhongSong DongLi Yan JiJia Ying ZhouZhi Hong ChenJian SuQing Ge ZhuMeng Min WangE E KeHao SunXue Tao LiJin Ji YangQing ZhouXu Chao ZhangXuan GaoXue Ning YangXuefeng XiaXin YiWen-Zhao ZhongYi Long WuPublished in: Thoracic cancer (2022)
Our study indicates the presence of intratumoral genetic heterogeneity and immune microenvironmental heterogeneity features in T4N0M0 NSCLCs, and the low degree of CIN may be related to the low metastatic capability.