RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding.

Ying LinYun WuQiangzu ZhangXunwei TuSufang ChenJunfan PanNengluan XuMing LinPeiwei SheGang NiuYusheng ChenHongru Li

Published in: Journal of experimental & clinical cancer research : CR (2024)

RPTOR is a key driver gene in the brain metastasis of lung cancer, which signifies that RPTOR blockade may serve as a promising therapeutic candidate for clinical application.

Keyphrases

brain metastases
small cell lung cancer
white matter
signaling pathway
copy number
genome wide
cerebral ischemia
genome wide identification
dna binding
advanced non small cell lung cancer
dna methylation