Enhanced renal clearance and impact on vancomycin pharmacokinetic parameters in patients with hemorrhagic stroke.
Kathryn A MorbitzerDenise H RhoneyKelly A DehneJ. Dedrick JordanPublished in: Journal of intensive care (2019)
Patients with hemorrhagic stroke and enhanced renal clearance displayed PK alterations favoring an increased elimination of vancomycin than expected. This may result in underexposure to vancomycin, leading to treatment failure.