[Induction of Uveitis by Immune-Oncologic Therapies, Namely Checkpoint Inhibitors].
Justus Gerhard GarwegPublished in: Klinische Monatsblatter fur Augenheilkunde (2022)
Given their impact onto the survival of cancer and namely melanoma patients, ICI and BRAF/MEK inhibitors are increasingly used alone and in combination, which enhances their inherent risk of developing drug-induced ocular autoimmunity. Favorable functional outcomes are closely linked to early recognition and aggressive treatment of these complications considering the fact that these immune-related adverse events affect multiple organ systems and have an untreated lethality of up to 3%.
Keyphrases
- drug induced
- liver injury
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- dna damage
- peritoneal dialysis
- prognostic factors
- papillary thyroid
- cell cycle
- juvenile idiopathic arthritis
- rheumatoid arthritis
- rectal cancer
- prostate cancer
- oxidative stress
- radical prostatectomy
- risk factors
- ankylosing spondylitis
- patient reported outcomes
- signaling pathway
- systemic lupus erythematosus
- squamous cell
- disease activity
- lymph node metastasis
- electronic health record