Smooth muscle Rac1 contributes to pulmonary hypertension.

Florian DilasserMarc RioLindsay RoseAngela TesseChristophe GuignabertGervaise LoirandVincent Sauzeau

Published in: British journal of pharmacology (2022)

Our results provide evidence for a protective effect of SM Rac1 deletion against hypoxic PH. Rac1 activity in PASMCs plays a causal role in PH by favouring ROS-dependent PA remodelling and endothelial dysfunction induced by chronic hypoxia.

Keyphrases

smooth muscle
pulmonary hypertension
cell migration
dna damage
pulmonary artery
endothelial cells
pulmonary arterial hypertension
reactive oxygen species