Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells.

Li WuJiayu ZhaoKexin CaoXiao LiuHao CaiJiaqi WangWeidong LiZhipeng Chen

Published in: Cell communication and signaling : CCS (2018)

The inhibitory effect of α-KG on ATP synthase was uncoupled with the tricarboxylic acid cycle and oxidative phosphorylation in SMMC-7721 cells; accordingly, energy metabolism was mainly determined by glycolysis. In drug-resistant cells, a remarkable reduction in the inhibitory effects of α-KG on ATP synthase resulted in better coordination among the TCA cycle, oxidative phosphorylation, and glycolysis, providing novel potential strategies for clinical treatment of liver cancer resistance.

Keyphrases

drug resistant
induced apoptosis
cell cycle arrest
multidrug resistant
protein kinase
acinetobacter baumannii
cell death
signaling pathway
cystic fibrosis
risk assessment
combination therapy