Almost 2% of Spanish breast cancer families are associated to germline pathogenic mutations in the ATM gene.

A Tavera-TapiaL Pérez-CaborneroJ A MacíasM I CeballosG RoncadorM de la HoyaA BarrosoV Felipe-PonceR Serrano-BlanchC HinojoM D Miramar-GallartM UriosteT CaldésS Santillan-GarzónJ BenitezAna Osorio

Published in: Breast cancer research and treatment (2016)

ATM mutation prevalence in Spanish population highlights the importance of considering ATM pathogenic variants linked to breast cancer susceptibility.

Keyphrases

dna repair
dna damage
dna damage response
copy number
risk factors
genome wide
oxidative stress
gene expression
dna methylation
breast cancer risk
transcription factor
genome wide identification