Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000-2022 in Northeastern Italy: Implication for Using p16 INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis.

Paolo Boscolo Rizzo Jerry Polesel Annarosa Del MistroElisabetta FrattaChiara LazzarinAnna MenegaldoValentina LupatoGiuseppe FanettiFabrizio ZanconatiMaria GuidoVittorio GiacomarraEnzo EmanuelliMargherita TofanelliGiancarlo Tirelli

Published in: Cancers (2023)

overexpression as a surrogate marker of transforming HPV infection, each institution should consider the subsite-specific prevalence rates of HPV-driven OPSCC as these significantly impact on its positive predictive value.

Keyphrases

high grade
squamous cell carcinoma
risk factors
cervical cancer screening
cell proliferation
transcription factor
lymph node metastasis
radiation therapy