Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis.
Xiaofang XuXianjun CaiXishi LiuSun-Wei GuoPublished in: Reproductive biology and endocrinology : RB&E (2021)
Our results suggest that SP, CGRP and noradrenaline may promote, while acetylcholine may stall, the progression of adenomyosis through their respective receptors on adenomyotic lesions. Additionally, through the activation of the hypothalamic-pituitary-adrenal (HPA)-sympatho-adrenal-medullary (SAM) axes and the lesional overexpression of ADRB2, adenomyosis-associated dysmenorrhea and adenomyotic lesions may be mutually promotional, forming a viscous feed-forward cycle.