Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy.
Annika LehnerLucas HoffmannStefan RamppRoland CorasFriedrich PaulsenRenato FrischknechtHajo M HamerKatrin WaltherSebastian BrandnerWiebke HoferTom PieperLea-Marie ReischChristian G BienIngmar BluemckePublished in: Epilepsia open (2024)
"Perineuronal nets" (PNN) are a specialized compartment of the extracellular matrix (ECM), especially surrounding highly active neurons of the mammalian brain. There is evidence that PNN play a role in memory formation, brain maturation, and in some pathologies like Alzheimer's disease, schizophrenia or epilepsy. In this study, we investigated the role of PNN in patients suffering from drug-resistant focal epilepsy compared to controls. We found that with increasing age, more neurons are surrounded by PNN. Similarly, all epilepsy patients but especially patients with better memory performance also had more PNN. This study raises further interest in studying ECM molecules in the human brain under physiological and pathophysiological conditions.
Keyphrases
- extracellular matrix
- drug resistant
- end stage renal disease
- ejection fraction
- newly diagnosed
- spinal cord
- peritoneal dialysis
- prognostic factors
- multidrug resistant
- endothelial cells
- bipolar disorder
- acinetobacter baumannii
- white matter
- working memory
- spinal cord injury
- cystic fibrosis
- patient reported outcomes
- blood brain barrier
- temporal lobe epilepsy