Gradient Photothermal Field for Precisely Directing Cell Sheet Detachment.

Due to the remaining intact intercellular interactions, cell sheets play increasing roles in biomedical fields. Recently, spatiotemporal control of cell sheets has become an urgent requirement in the context of precise surgery. Here, the development of a gradient photothermal biointerface for precisely directing cell sheet detachment through quantitatively regulating the dissociation rate of collagen is reported. This novel and facile method shows great potential for application in precise regenerative medicine.