The brain-penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion-induced emesis in Suncus murinus (house musk shrew).

Longlong TuZengbing LuMan P NganFrancis F Y LamClaudio GiulianoEmanuela LovatiClaudio PietraJohn A Rudd

Published in: British journal of pharmacology (2020)

HM01 is more effective than HM02 in preventing motion-induced emesis. The difference in potency may relate to activation of ghrelin receptors in the PVH.

Keyphrases

high glucose
diabetic rats
drug induced
high speed
white matter
endothelial cells
oxidative stress
mass spectrometry
brain injury
stress induced