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Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies.

Daniel StrüderTheresa MomperNina IrmscherMareike KrauseJan LieseSebastian SchravenAnnette ZimpferSarah ZonnurAnn-Sophie BurmeisterBjörn SchneiderBernhard FrerichRobert MlynskiChristina Große-ThieChristian JunghanssClaudia Maletzki
Published in: Journal of experimental & clinical cancer research : CR (2021)
Including biopsy samples from locally advanced or metastatic lesions from patients with non-surgical treatment strategies, increases the availability of PDX for basic and translational research. This facilitates (pre-) clinical studies for individual response prediction based on immunological biomarkers.
Keyphrases
  • ultrasound guided
  • fine needle aspiration
  • locally advanced
  • squamous cell carcinoma
  • rectal cancer
  • neoadjuvant chemotherapy
  • small cell lung cancer
  • phase ii study
  • radiation therapy
  • clinical trial