MR-LINAC, a New Partner in Radiation Oncology: Current Landscape.
Abrahams OcantoLisselott TorresMiguel MontijanoDiego RincónCastalia FernándezBeatriz SevillaDaniela GonsalvesMacarena TejaMarcos GuijarroLuis GlaríaRaúl HernánzJuan Zafra MartínNoelia SanmamedAmar KishanFilippo AlongiDrew MoghanakiHimanshu NagarFelipe CouñagoPublished in: Cancers (2024)
Technological advances in radiation oncology are oriented towards improving treatment precision and tumor control. Among these advances, magnetic-resonance-image-guided radiation therapy (MRgRT) stands out, with technological advances to deliver targeted treatments adapted to a tumor's anatomy on the day while minimizing incidental exposure to organs at risk, offering an unprecedented therapeutic advantage compared to X-ray-based IGRT delivery systems. This new technology changes the traditional workflow in radiation oncology and requires an evolution in team coordination to administer more precise treatments. Once implemented, it paves the way for newer indication for radiation therapy to safely deliver higher doses than ever before, with better preservation of healthy tissues to optimize patient outcomes. In this narrative review, we assess the technical aspects of the novel linear accelerators that can deliver MRgRT and summarize the available published experience to date, focusing on oncological results and future challenges.
Keyphrases
- radiation therapy
- magnetic resonance
- contrast enhanced
- gene expression
- radiation induced
- high resolution
- palliative care
- locally advanced
- quality improvement
- prostate cancer
- cancer therapy
- single cell
- magnetic resonance imaging
- systematic review
- computed tomography
- combination therapy
- minimally invasive
- replacement therapy
- neural network