Cu-Catalyzed Three-Component Carboamination of Electron Deficient Olefins.
Aja M NicelyAndrei G PopovHannah C WendlandtGrace L TrammelDaniel G KohlerKami L HullPublished in: Organic letters (2023)
The copper-catalyzed three-component carboamination of atropates for the synthesis of α-aryl amino acid derivatives is presented. The scope of the reaction is explored with respect to all three coupling partners: the alkyl halide, the atropate, and the aryl amine. A total of 41 examples are included, with yields of ≤92%. Both primary and secondary aryl amines participate in the carboamination along with α-haloesters, nitriles, and perfluoroiodoalkanes. Mechanistic investigations support a radical mechanism involving Cu-mediated C-N bond formation with the radical adduct.