Linaclotide inhibits colonic and urinary bladder hypersensitivity in adult female rats following unpredictable neonatal stress.

Casey O LigonE MohammadiP GeG HannigC HigginsBeverley Greenwood-Van Meerveld

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

Our results demonstrate that neonatal rats exposed to unpredictable ELS develop increased sensitivity and permeability of the colon and bladder in adulthood through a mechanism involving activation of peripheral GC-C signaling.

Keyphrases

stress induced
spinal cord injury
endothelial cells
drug induced
early life
high resolution
young adults
mass spectrometry
heat stress
childhood cancer
simultaneous determination