Severe delayed pulmonary toxicity following PD-L1-specific CAR-T cell therapy for non-small cell lung cancer.
Heping LiuYuxiang MaChaopin YangShangzhou XiaQiuzhong PanHongyun ZhaoWenfeng FangXi ChenYang ZhangBenyan ZouQiuyuan LiYang WanHao ChenYan TangJingjing ZhaoDesheng WengLiming XiaLi ZhangJian-Chuan XiaPublished in: Clinical & translational immunology (2020)
The clinical manifestations and test findings for this patient with NSCLC might represent unique clinical manifestations of solitary organ damage secondary to PD-L1-specific CAR-T cell therapy. The differential diagnosis, underlying mechanism and prevention and treatment strategies for such complications have also been discussed.