[18 F]GE180 positron emission tomographic imaging indicates a potential double-hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Mirjam BrackhanPablo BascuñanaTobias L RossFrank M BengelJens P BankstahlMarion BankstahlPublished in: Epilepsia (2018)
TSPO in vivo imaging reliably detects brain inflammation during epileptogenesis. These inflammatory processes most prominently affect the hippocampus ipsilateral to the injection site. Inflammation induced by the traumatic insult associated with surgery synergistically contributes to total brain inflammation and may also contribute to epileptogenesis. The revealed time course of neuroinflammation will help to identify appropriate time points for anti-inflammatory, potentially antiepileptogenic treatment.
Keyphrases
- temporal lobe epilepsy
- oxidative stress
- cerebral ischemia
- mouse model
- high resolution
- white matter
- anti inflammatory
- minimally invasive
- spinal cord injury
- traumatic brain injury
- cognitive impairment
- subarachnoid hemorrhage
- lipopolysaccharide induced
- coronary artery bypass
- multiple sclerosis
- blood brain barrier
- inflammatory response
- coronary artery disease
- mass spectrometry
- single cell
- brain injury
- photodynamic therapy
- acute coronary syndrome
- combination therapy