Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.
Pieter Jelle VisserLianne M ReusJohan GobomIris JansenEllen DicksSven J van der LeeMagda TsolakiFrans R J VerheyJulius PoppPablo Martinez-LageRik VandenbergheAlberto LleóJosé Luís MolinuevoSebastiaan EngelborghsYvonne Freund-LeviLutz FroelichKristel SleegersValerija DobricicSimon LovestoneJohannes StrefferStephanie J B VosIsabelle Bosnull nullAugust B SmitKaj BlennowPhilip ScheltensCharlotte E TeunissenLars BertramHenrik ZetterbergBetty M TijmsPublished in: Molecular neurodegeneration (2022)
CSF t-tau levels in AD are associated with altered levels of proteins involved in neuronal plasticity and blood-brain and blood-CSF barrier dysfunction. Future trials may need to stratify on CSF t-tau status, as AD individuals with increased t-tau and normal t-tau are likely to respond differently to treatment, given their opposite CSF proteomic profiles.