Existing and emerging therapies for the treatment of invasive candidiasis and candidemia.
David De BelsEvelyne MaillartFrançoise Van BambekeSebastien RedantPatrick M HonoréPublished in: Expert opinion on emerging drugs (2022)
While new formulations (amphotericin B cochleate) improve oral bioavailability of the corresponding drugs, new azoles or echinocandins offer higher potency including against strains resistant to former generations of drugs. Repurposed drugs show synergism with current therapies in vitro. Results from ongoing and future clinical trials will be decisive to establish the interest for these drugs in our arsenal.