Bacterial reduction and shift with NPWT after surgical debridements: a retrospective cohort study.
Thorsten JentzschGeorg OsterhoffPawel ZwolakBurkhardt SeifertValentin NeuhausHans-Peter SimmenGerrolt N JukemaPublished in: Archives of orthopaedic and trauma surgery (2016)
The treatment regimen of combined use of repetitive debridement, irrigation and NPWT in an operating room with antibiotics significantly reduced the bacterial load and led to a shift away from Gram-positive bacteria, facultative anaerobic bacteria, and S. aureus, as well as questionably toward CoNS and Pseudomonas spp. in this patient cohort. High rates of wound closure were achieved in a relatively short time with low revision rates. Whether each modality played a role for these findings remains unknown.