Brown Seaweed Egregia menziesii's Cytotoxic Activity against Brain Cancer Cell Lines.
Tatiana N Olivares-BañuelosAnllely G Gutiérrez-RodríguezRodolfo Méndez-BellidoRicardo Tovar-MirandaOmar Arroyo-HelgueraClaudia Juárez-PortillaThuluz Meza-MenchacaLuis E Aguilar-RosasLuisa C R Hernández-KellyArturo OrtegaRossana Citlali ZepedaPublished in: Molecules (Basel, Switzerland) (2019)
Brown seaweeds contain bioactive compounds that show anti-tumorigenic effects. These characteristics have been repeatedly observed in the Lessoniaceae family. Egregia menziesii, a member of this family, is distributed in the North Pacific and its properties have been barely studied. We evaluated herein the cytotoxic and anti-proliferative activity of extracts of this seaweed, through toxicity assay in Artemia salina and lymphocytes, and MTT proliferation assay, in Bergmann glia cells, 3T3-L1 and brain cancer cell lines. E. menziesii's extracts inhibited the spread of all the tested cell lines. The hexane extract showed the highest cytotoxic activity, while the methanol extract was moderately cytotoxic. Interestingly, seaweed extracts displayed a selective inhibition pattern. These results suggest that E. menziesii's extracts might be good candidates for cancer prevention and the development of novel chemotherapies due to its highest cytotoxicity in transformed cells compare to glia primary cultures.
Keyphrases
- papillary thyroid
- induced apoptosis
- oxidative stress
- squamous cell
- cell cycle arrest
- high throughput
- resting state
- signaling pathway
- lymph node metastasis
- white matter
- squamous cell carcinoma
- endoplasmic reticulum stress
- functional connectivity
- cell death
- peripheral blood
- multiple sclerosis
- young adults
- subarachnoid hemorrhage