Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer.

Liwei Lang Fanghui Chen Yamin Li Chloe Shay Fan Yang Hancai Dan Zhuo G Chen Nabil F Saba Yong Teng

Published in: Cancer research communications (2023)

This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.

Keyphrases

cancer stem cells
tyrosine kinase
early stage
dna damage response
radiation therapy
locally advanced
squamous cell carcinoma
oxidative stress
radiation induced
dna damage
rectal cancer
dna repair