Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
Boyu ChiAilin ZouLipeng MaoDabei CaiTingting XiaoYu WangQingjie WangYuan JiLing SunPublished in: Oxidative medicine and cellular longevity (2023)
Our data suggest that EMPA-sEV significantly improve cardiac repair after MI by inhibiting myocardial apoptosis. miR-214-3p at least partially mediated the myocardial protection of EMPA-sEV through the AKT signaling pathway.
Keyphrases
- signaling pathway
- left ventricular
- pi k akt
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- heart failure
- oxidative stress
- stem cells
- endoplasmic reticulum stress
- bone marrow
- electronic health record
- cell death
- big data
- cell proliferation
- atrial fibrillation
- machine learning
- data analysis
- deep learning