Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells.
Ziwen CaiMiaomiao ZhuLi XuYue WangYin XuWai Yen YimHong CaoRuikang GuoXiang QiuXimiao HeJiawei ShiWeiHua QiaoNianguo DongPublished in: Circulation (2024)
In summary, this is the first study to report an efficient strategy to generate functional hiPSC-derived valve endothelial-like cells and hiPSC-derived valve interstitial-like cells from hiPSCs, as well as to elucidate the differentiation trajectory and transcriptional dynamics of hiPSCs differentiated into heart valve cells.
Keyphrases
- aortic valve
- induced pluripotent stem cells
- mitral valve
- induced apoptosis
- aortic stenosis
- endothelial cells
- cell cycle arrest
- heart failure
- transcatheter aortic valve replacement
- atrial fibrillation
- oxidative stress
- ejection fraction
- signaling pathway
- endoplasmic reticulum stress
- cell death
- coronary artery disease
- left ventricular
- pi k akt
- cell proliferation