Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [ 18 F]PSS232 PET/MRI study.
Jie WangYingfang HeXing ChenLin HuangJunpeng LiZhiwen YouQi HuangShuhua RenKun HeRoger SchibliLinjing MuYihui GuanQihao GuoJun ZhaoFang XiePublished in: Alzheimer's research & therapy (2024)
F]PSS232 PET can quantify the changes of mGluR5 availability in the progression of AD. mGluR5 availability correlated not only with neuropathological biomarkers of AD but also with neurodegenerative biomarkers and cognitive performance. mGluR5 may be a novel neurodegenerative biomarker, and whether mGluR5 could be a potential therapeutic target for AD needs to be further studied.