Extracellular vesicles secreted by human aneuploid embryos present a distinct transcriptomic profile and upregulate MUC1 transcription in decidualised endometrial stromal cells.

Sofia MakievaElisa GiacominiGiulia Maria ScottiDejan LazarevicValentina PavoneJessica OttolinaLudovica BartiromoMatteo SchimberniMarco MorelliAlessandra AlteriSabrina MinettoGiovanni TononMassimo CandianiEnrico PapaleoPaola Vigano

Published in: Human reproduction open (2024)

The study was supported by a Marie Skłodowska-Curie Actions fellowship awarded to SM by the European Commission (CERVINO grant agreement ID: 79620) and by a BIRTH research grant from Theramex HQ UK Ltd. The authors have no conflicts of interest to declare.

Keyphrases

endothelial cells
induced pluripotent stem cells
rna seq
gestational age
endometrial cancer
preterm birth