High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage.

Harald KrenzlinChristina FrenzJan SchmittJulia Masomi-BornwasserDominik WespDarius KalasauskasThomas KerzJohannes LotzBeat AlessandriFlorian RingelNaureen Keric

Published in: PloS one (2020)

In this study we found that initial thrombin concentration and activity in CSF of ICH patients did not correlate with ICH and IVH volume but are associated with a poorer functional neurological outcome. These findings support mounting evidence of the role of thrombin as a contributor to secondary injury formation after ICH.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
brain injury
peritoneal dialysis
prognostic factors
patient reported
cerebral ischemia