High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway.
Zhaowei WenHuiying SunZhihua ZhangYannan ZhengSiting ZhengJianping BinYulin LiaoMin ShiRui ZhouWang-Jun LiaoPublished in: Cancer communications (London, England) (2023)
M2-like macrophages via the IGFBP2-STAT3-PD-L1 signaling pathway and their substantial inhibitory effects on T cell proliferation and activation.