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A stochastic model of blood flow to calculate blood dose during radiotherapy.

Chris BeekmanJulia D WithrowCamilo M Correa-AlfonsoShreya PathakRobert J DawsonNatalia Carrasco-RojasAndrew SforzaCarlos ColonWesley E BolchClemens GrassbergerHarald Paganetti
Published in: Physics in medicine and biology (2023)
The ability to report the blood dose distribution during radiotherapy is imperative to test and act upon the current paradigm that radiation-induced lymphopenia is caused by direct cell killing of lymphocytes in the blood. We have built a general model that can do so for various treatment sites. The presented framework is publicly available at https://github.com/mghro/hedos.
Keyphrases
  • radiation induced
  • blood flow
  • radiation therapy
  • locally advanced
  • squamous cell carcinoma
  • cell therapy
  • stem cells
  • peripheral blood
  • mesenchymal stem cells